Solvias offers a seamless approach to design and optimize a robust and scalable crystallization process together with kilogram supply of API under GMP, if required:

Polymorphism Investigation

• Determination of relevant polymorphic forms
• Evaluation of polymorphic transformations
• Identification of thermodynamic most stable form 

Form Selection & Process Design

• Temperature-dependent solubility
• Identification of metastable zone width
• Variation of crystallization techniques, 
  solvents, process parameters

Crystallization Process Optimization

• Optimization of process parameter and
• bulk properties

Multigram to Kilogram Supply

• Crystallization on kilogram scale
• (GMP/non-GMP)
• Technical transfer of crystallization process