Physical Chemistry

Within this area we not only provide you with single parameters but also with extensive evaluations like polymorphism studies, stability studies, surface evaluations and many more.

Solids

Thermal Methods

  • DSC
  • thermogravimetry (TG)
  • high sensitivity isothermal calorimetry
  • depolarization
  • vapor pressure (10-5 Pa to 100 kPa, R.T. to 400 °C,
    also very high precision from 0.1 Pa to 1 kPa)

Dynamic Vapor Sorption

X-Ray Powder Diffraction

  • controlled temperature
  • controlled atmosphere (gas or humidity)

Coupled Methods

  • TG-FTIR
  • IR-microscopy
  • hot stage Raman- microscopy
  • hot stage microscopy


Particles/Formulations


Particle Sizing

  • laser light diffraction
  • quasi-elastic light scattering
  • sieving
  • disc-centrifugation
  • gas sorption methods
  • He- and Hg-density, tapped density
  • specific surface

Electrokinetic Sonic Amplitude

Zeta Potential

Surfaces

Microscopy

  • light microscopy
  • SEM, TEM, EDX elemental analysis (mapping)
  • image processing

Ellipsometry

Contact Angle Measurements


Molecular Properties and Interactions

Analytical Ultracentrifugation

Titration Calorimetry

Spectroscopy

  • IR (incl. ATR), Raman
  • NMR
  • UV/VIS/NIR
  • reflectance spectroscopy
  • fluorescence, phosphorescence (time resolved and stopped-flow)
  • chemiluminescence
  • singlet oxygen
  • polarimetry, ORD
  • CD

Physicochemical Constants

  • density
  • viscosity
  • logP
  • conductivity
  • solubility
  • surface tension
  • refractive index
  • osmotic pressure
  • melting point
  • specific heat

Rheology: η’(ω),η’’(ω)

  • oscillation experiments
  • yield stress
  • creep recovery

Radiometry

  • EN 45001 certified
  • IR-camera

Model calculations

  • kinetics
  • diffusion
  • multiple equilibria
  • optimal spectral properties

Polymorphism, Salts and Crystallization 

  • comprehensive salt- & polymorphism screening
  • find all relevant forms
  • polymorphic purity
  • complete characterization
  • patent life extension
  • free energy - temperature diagram

Optimization of Processes 

  • distillation
  • crystallization
  • lyophilization
  • drying

Quality control 

  • single parameters
  • packages

Preformulation Characterization 

Binding Studies

  • K, k, ΔG, ΔH, ΔS, stoichiometry
  • protein/drug, protein/protein, nucleic acid/drug etc.

Structure of Biomaterials

  • structure of biomacromolecules and cell components
  • preparation techniques (e.g. staining, immunolabeling)

Stability Studies of Active Substances and Formulations

  • thermal stability
  • light stability
  • hydrolytic stability

Formulation Development

  • suspensions
  • creams
  • parenteral dosage forms etc.

Surface Characterization

  • surface morphology and roughness
  • surface energy
  • surface functionalization and patterning

Properties of Macromolecules (biological/technical)

  • molar mass, size, selfassociation
  • sedimentation coefficient
  • protein denaturing/folding

Application Properties

  • spectra, colors, activities
  • quantum yields (fluorescence, photoreactions, phosphorescence, chemiluminescence)

Application Problems: Causes and Remedies

  • photostability/photodegradation
  • thermal/chemical stability/degradation
  • discolorations/yellowing

Calibration of Light Sources and Detectors

  • absolute spectral calibration
  • calibration on-site
  • consulting for medical and technical irradiation setups 

 IR-Thermography/2-dimensional
Analysis of Heating Effects

  • screening of exothermal reactions in microtiter plates
  • heat dissipation on chemical production sites

Consulting

  • optimal processing of experimental data (e.g. kinetic analyses)
  • strategies in medical diagnostics

Contract Research

  • development of new formulations
  • improvement of diagnostic sensitivity
  • HTS strategies
  • rapidly decaying drug-carriers

image: Physical Chemistry Fingerprints of a solid revealed by powder X-ray diffraction

image: Physical Chemistry Fingerprints of a solid revealed by powder X-ray diffraction«Fingerprints» of a solid revealed by powder X-ray diffraction