Physical Chemistry
Within this area we not only provide you with single parameters but also with extensive evaluations like polymorphism studies, stability studies, surface evaluations and many more.
Solids
Thermal Methods
- DSC
- thermogravimetry (TG)
- high sensitivity isothermal calorimetry
- depolarization
- vapor pressure (10-5 Pa to 100 kPa, R.T. to 400 °C,
also very high precision from 0.1 Pa to 1 kPa)
Dynamic Vapor Sorption
X-Ray Powder Diffraction
- controlled temperature
- controlled atmosphere (gas or humidity)
Coupled Methods
- TG-FTIR
- IR-microscopy
- hot stage Raman- microscopy
- hot stage microscopy
Particles/Formulations
Particle Sizing
- laser light diffraction
- quasi-elastic light scattering
- sieving
- disc-centrifugation
- gas sorption methods
- He- and Hg-density, tapped density
- specific surface
Electrokinetic Sonic Amplitude
Zeta Potential
Surfaces
Microscopy
- light microscopy
- SEM, TEM, EDX elemental analysis (mapping)
- image processing
Ellipsometry
Contact Angle Measurements
Molecular Properties and Interactions
Analytical Ultracentrifugation
Titration Calorimetry
Spectroscopy
- IR (incl. ATR), Raman
- NMR
- UV/VIS/NIR
- reflectance spectroscopy
- fluorescence, phosphorescence (time resolved and stopped-flow)
- chemiluminescence
- singlet oxygen
- polarimetry, ORD
- CD
Physicochemical Constants
- density
- viscosity
- logP
- conductivity
- solubility
- surface tension
- refractive index
- osmotic pressure
- melting point
- specific heat
Rheology: η’(ω),η’’(ω)
- oscillation experiments
- yield stress
- creep recovery
Radiometry
- EN 45001 certified
- IR-camera
Model calculations
- kinetics
- diffusion
- multiple equilibria
- optimal spectral properties
Polymorphism, Salts and Crystallization
- comprehensive salt- & polymorphism screening
- find all relevant forms
- polymorphic purity
- complete characterization
- patent life extension
- free energy - temperature diagram
Optimization of Processes
- distillation
- crystallization
- lyophilization
- drying
Quality control
- single parameters
- packages
Preformulation Characterization
Binding Studies
- K, k, ΔG, ΔH, ΔS, stoichiometry
- protein/drug, protein/protein, nucleic acid/drug etc.
Structure of Biomaterials
- structure of biomacromolecules and cell components
- preparation techniques (e.g. staining, immunolabeling)
Stability Studies of Active Substances and Formulations
- thermal stability
- light stability
- hydrolytic stability
Formulation Development
- suspensions
- creams
- parenteral dosage forms etc.
Surface Characterization
- surface morphology and roughness
- surface energy
- surface functionalization and patterning
Properties of Macromolecules (biological/technical)
- molar mass, size, selfassociation
- sedimentation coefficient
- protein denaturing/folding
Application Properties
- spectra, colors, activities
- quantum yields (fluorescence, photoreactions, phosphorescence, chemiluminescence)
Application Problems: Causes and Remedies
- photostability/photodegradation
- thermal/chemical stability/degradation
- discolorations/yellowing
Calibration of Light Sources and Detectors
- absolute spectral calibration
- calibration on-site
- consulting for medical and technical irradiation setups
IR-Thermography/2-dimensional
Analysis of Heating Effects
- screening of exothermal reactions in microtiter plates
- heat dissipation on chemical production sites
Consulting
- optimal processing of experimental data (e.g. kinetic analyses)
- strategies in medical diagnostics
Contract Research
- development of new formulations
- improvement of diagnostic sensitivity
- HTS strategies
- rapidly decaying drug-carriers
Crystals in hot stage microscope
image: Physical Chemistry Fingerprints of a solid revealed by powder X-ray diffraction
«Fingerprints» of a solid revealed by powder X-ray diffraction
