Pharmaceutical Tests

Adsorbable organically bound halogen (AOX)
Amino acid analysis (AAA, Biochrom)
Analytical ultracentrifugation (AUC)
Analyzers for TOC, AOX, POCl, TON, DOC
Atomic absorption spectrometr y (FAAS, ETAAS, CVAAS)

Boiling point


Capillary electrophoresis (CE, various Beckmann and Agilent instruments, options for detection include UV absorbance with DAD, LIF and UV-CCD
capillary imaging)

Capillary viscosimeter
Chemstation Plus system (HPLC, GC, CE)
Chiral separation techniques (CE, HPLC, GC)
Chromatography(All modes of LC, GC, many options of detectors and hyphenation)

Circular dichroism (CD)
Combustion analysis (C, H, N, O, S, halogens, residue on ignition)
Conductivity measurements
Confocal laser scanning microscopy
Contact angle measurements
Controlled stress rheometer

Densitometer (UV/VIS, fluorescence)
Density measurements (fluids, powders)
Differential scanning calorimetry (DSC)
Dissolution calorimetry
Dissolution testing (USP 1, USP 2, static, intrinsic)
Dissolved organic carbon (DOC)
Dissolved organic nitrogen (DON)
DNA preparation
DNA sequencing (ABI prism 7700, AB 3730xl)
Dynamic vapor sorption (DVS)

EDX (energy dispersive X-ray analysis)
Electroanalytical methods (polarography,
tensammetry, voltammetry, coulometry, amperometry, electrosynthesis)

Electrokinetic sonic amplitude (ESA)
Electron microscopy (SEM, TEM)
Electrophoresis (capillary or slab-gel formats)
Elemental analysis (see combustion analysis)
Endotoxin determination (LAL)

Fluorescence microscopy
Fluorescence spectroscopy
Fourier transform infrared spectroscopy (FTIR)

Gas chromatography (MS, ECD, NPD, WLD, FID,
micro-GC, headspace GC)

Halogen, halogenide determinations
Headspace gas chromatography (static, dynamic)
Heavy metal screening
Hot stage Raman microscopy
Hot stage X-ray diffraction analysis (controlled
temperature and humidity)
High Per formance Liquid Chromatography (HPLC,
see chromatography)

High Per formance Liquid Chromatography (HPLC,
see chromatography)
Hyphenated techniques (LC-MS, GC-MS, headspace

Inductively coupled plasma atomic emission spectrometry (ICP-OES)
Infrared microscopy
Infrared spectroscopy (see fourier transform infrared spectroscopy)

Inductively coupled plasma mass apectrometry (ICP-MS)

Ion chromatography (Dionex HPAEC with PAD, see chromatography
Isoelectric focussing (capillary or slab-gel formats)
Isothermal titration calorimetry (ITC)

Karl-Fischer water determination (special equipment to determine water content in lyophilisates and ampoules)
Kjeldahl nitrogen determination

LAL testing (endotoxins)
Liquid chromatography, see HPLC

Mass spectrometry (several modes, ES-MSn, MALDI-TOF/TOF MS, ICP-MS)
Micro analytical combustion methods (see combustion analysis)

Micro GC
Micro methods for the determination of water content

(Karl Fischer titration). Special equipment to determine water
content in lyophilisates and ampoules
Micro titrations, macro titrations
Microbiological testing
Microplate reader
Microscopy (light microscopy, SEM, TEM, EDX elemental analysis,

Raman, fluorescence, confocal)
MiniAPI (biochemical identification of bacteria)

Nitrogen determination according to Kjeldahl
Nuclear magnetic resonance spectroscopy (NMR)

Optical emission spectrometry (ICP-OES, fluorescence, phosphorescence)
Optical rotatory dispersion (ORD)
Osmolality, osmolarity (freezing point depression)

Particle sizing (laser light dif fraction, sieving, microscopical)
Peltier-based and gradient thermocyclers
Peptide mapping (LC-MS/MS for identification, LC-UV for quantification)
Pharmacopeial methods (USP, Pharm. Eur., BP, JP,
Pharm. Helv.)
Physical measurements (density, viscosity, log P, pKa,

conductivity, solubility, sur face tension, refractive index, osmotic pressure, melting point, specific heat capacity)
POCI (purgeable organic halogens)
Polarimetry, ORD

Quantitative polymerase chain reaction (QPCR)

Raman microscopy
Raman spectroscopy, Fourier transform (FT Raman)
Real time PCR (see quantitative polymerase chain reaction)

Reflectance spectroscopy
Residual DNA (Threshold, Q-PCR)
Rheology, including oscillation, yield stress etc.
Robots (Biomek 2000, Hydra, BioRobot 9600)

Scanning electron microscopy with energy
dispersive X-ray analysis (EDX)
Slab-gel electrophoresis (SDS-PAGE, with visualisation using Coomassie brilliant bue, silver staining or western blotting)
Size exclusion chromatography (SEC)
Solubility measurements
Spectroscopy (IR, Raman, NMR, MS, fluorescence,
phosphorescence, UV/VIS, CD)
Surface tension (plate and ring methods)
Sympatec Helos (particle sizing)

Thermogravimetry (TG, TG-FTIR)
ThresholdTM (molecular devices, for residual DNA)
Titration calorimetry
TLC, including application devices and scanners
Total organic carbon (TOC)
Total bound nitrogen (TON)
Trace analysis
Transmission electron microscopy (TEM)

Ultracentrifuge, analytical (AUC)

Vapor pressure measurements
Vapor sorption measurements (DVS)
Videodensitometry, quantitative and qualitative
Viscosity measurements (capillary and rheometer)


Water determination (see Karl Fischer)

Water for pharmaceutical purposes, microbiological and physicochemical testing
Western blotting

X-ray fluorescence spectrometry (XRF)
X-ray powder diffraction (XRPD)

Zeta potential (ESA)

Slab-gel electrophoresis (SDS-PAGE, with
visualisation using Coomassie brilliant bue, silver
staining or western blotting)