Custom Synthesis

Solvias provides custom synthesis, from milligram to kilogram scale, of your small molecules. Our expertise and services include:

  • Lead synthesis and optimization of pre-clinical candidates
  • Synthesis/Isolation of impurities, metabolites, degradants and reference compounds
  • Synthesis of scaffolds and building blocks

You brief us on your molecule’s structure, and our team then synthesizes your molecule for patent coverage, for early-phase studies, or to support your in-house Medicinal Chemistry group in meeting your timelines.

You can either supply a synthetic route, or, where necessary, we can develop new, innovative solutions for your molecule. Contracts are based on a fixed-price quotation, or can be – for larger projects (programs) – arranged on a fixed-term basis, resulting in a more flexible and interactive collaboration. Overall, we guarantee fast turnaround, high purity and timely delivery of your compounds.

In addition, impurities, degradants or metabolites can be isolated by preparative HPLC and then further characterized using state-of-the-art techniques such as nuclear magnetic resonance (NMR), mass spectrometry (MS), raman, infrared (FTIR) and ultra-violet (UV) or hyphenated techniques such as LC-MS/MS and LC-Accurate Mass, to fully characterize your material.

Solvias’ facilities are equipped with the latest process and analytical instrumentation. Combined with its extensive range of scale-up equipment and key areas of expertise, Solvias’ scientists have the experience and professionalism to move your projects forward.