High Throughput Screening

Solvias offers rapid evaluation of chemo-, biocatalysis and classical resolution steps to identify economically feasible routes on behalf of its customers using a state of the art HTS-infrastructure. Solvias started implementing HT-Screening services in the area of asymmetric hydrogenation in 2006. Since then, the capabilities have been successively expanded in the fields of CX-coupling, heterogeneous hydrogenation, biocatalysis and racemic resolution as well as customized screening capabilities in the rapidly growing area of organocatalysis. This fast and cost effective solution can enhance the route selection process for any chiral and non chiral intermediate or API. We assist you in selecting the most ecomically visible route taking your development stage into consideration. Complemented by scale-up and manufacturing capabilities for APIs up to clinical phase II, Solvias supports its customers during the entire chemical and analytical development process.

Asymmetric Homogeneous Catalysis
Whenever you need to develop or optimize an asymmetric homogeneous catalyzed process, Solvias is your partner of choice. With a unprecedented track record in asymmetric hydrogenation and various others successfully developed chiral process we have the experience and infrastructure including a large ligand library for a successful project outcome. Customers can benefit from standardized plates at a low price to highly sophisticated customized plates running even the most complex catalytic chemistry.

Biocatalysis
Our service offering ranges from initial screening to comprehensive process devlopment for a biocatalytic route. Our enzyme collection contains 200 proprietary enzymes (mainly Ketoreductases) from various established providers, which are all available in industrial quantities.

Racemic resolution
Separation of racemic mixtures by the formation and crystallization of diastereomeric salts (classical resolution) is an important process in the pharmaceutical industry. Classical resolution is generally performed using either 32 chiral acids or bases, respectively depending on the substrate and pKa values. Experiments are generally conducted on a 0.4 ml scale and analysis and determination of enantiomeric excess (ee) using supercritical fluid chromatography (SCF).

CX-Coupling
We offer screnning and process optimzation for todays important and industrial relevant CX-coupling chemistry, incl. Suzuki-Miyaura coupling, Buchwald-Hartwig Amination, Negishi coupling and other C-C transformations such as carbonylation, and hydroformylation. Accompanied by a strong portfolio of available in-house (non) proprietray CX-coupling catalysts we rapidly identify scalable and industrial relevant solutions for your intermnediate and API.

Heterogeneous Hydrogenation
Identifying a heterogeneous catalyst which provides high selectivity and activity in a multifunctional substrate requires expertise and experience, when screening variables such as metal, reaction medium, type of catalyst support and reaction conditions. With our breadth of experience examplified by our in-house database covering > 33'000 of transformations in heterogenous hydrogenation, we are a center of excellence.

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High Throughput Screening

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96 well-plates