Solvias Salt Program
Often new substances showing pharmaceutical activity are weak acids or bases, which have very low water solubility. In such cases, it may be preferable to market the drug as a salt form with better solubility. The aim of a salt program, i. e., salt screening and salt selection, is to screen for crystalline salts of a compound and to select the best candidate(s) for further development. This selection is based on, among other considerations, physical and chemical parameters such as stability, solubility and hygroscopicity.
Features of Solvias Salt Program
- Efficient and focused program: Starting with a large selection of salts, a limited number of leads is created and characterized in more detail
- Broad screening with small amount of substance thanks to microscopic crystallization screening
- Flexibility: Modular approach, with decision points during the program
- Strategy is adapted to properties of substance: Depending on difficulty to obtain crystalline salts, we adjust the number and type of crytallization conditions
- A large palette of options is available subsequent to salt selection, such as adapted polymorphism programs, stability testing, crystallization optimization, analytical development, and intellectual property support
