Solvias Prospects

1/08 Prospects (download PDF)

The Role of Process R&D in Early Chemical Development: Pay Now or Pay Later
Under what circumstances should a company invest in early-phase process development?
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Microbiological Testing: Harmonization Between the Major Pharmacopoeias
In a major step towards global harmonization of pharmaceutical product testing, the European, United States and Japanese Pharmacopoeias have revised their regulations on microbiology testing.
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Crystallization Development – The Final Step Towards an Optimized Drug Substance
Always a critical development step, crystallization is increasingly important in the isolation and purification of drug substances.
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Better Process Monitoring with Near Infrared Spectroscopy Innovations in process analytical technology (PAT) can provide you with a wealth of information that can give you more accurate information throughout the manufacturing process and help you improve your quality control. 
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1/07

Analysis of Highly Active and Highly Toxic Substances
In recent years, the number of extremely active and toxic active substances in the pharmaceutical industry has greatly increased. Solvias is now able to offer virtually comprehensive analytical services for highly hazardous substances
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Lautens Technology: A Novel Scalable Synthetic Method for Highly Functionalized Chiral Scaffolds
The powerful chemo-catalytic method developed by Professor Mark Lautens and his research group at the University of Toronto, Canada provides a novel technique enabling the production of these core structures in enatioenriched form
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Co-Crystals - An Attractive Alternative for Solid Forms
Solvias' extensive work on co-crystallization has yielded a three-phase program that includes co-crystal screening to determine the best solid form
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1/06

Amorphous Phase Content Determination
Solvias has long-standing experience in isothermal calorimetry and its use in amorphous content determination
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CN-Coupling: ppm-Level Catalyst Loading for
Efficient Buchwald-Hartwig Amination
Solvias has exclusively licensed a highly efficient CN-coupling technology for aromatic and heteroaromatic chlorides, bromides and sulfonates with amines and imines from Yale University
(US patents 5,977,361 and US 6,235,938 B1)
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NEW! High Throughput Catalysis Screening Services
Solvias launches its first full-scale HTS Screening Service for
asymmetric homogeneous hydrogenation
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2/05

Determination of Detergents
in Therapeutic Protein Substances
Due to significant market demand for the determination of Tween in trace and low concentrations, Solvias has developed methods for Tween quantification in protein formulations that can be validated
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UV-SPECTOR Application
Inline Monitoring of Chromatographic Steps - Improved Quality and Yield in Biopharmaceutical Processing
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Industrial Hygiene - Exposure Assessment,
Risk Appraisal, Action Plan
Solvias can provide not only exposure measurement, but also assessment of particular industrial hygiene settings, and can moreover propose problem-solving approaches for remediating identified safety issues
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Crystallization:
Its Relevance During Solid-State Development
Solvias has developed a modular approach to crystallization screening
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Selective Heterogeneous Hydrogenation
The potential of modern heterogeneous hydrogenation catalysts
for the selective, efficient synthesis and manufacture of complicated, multifunctional target molecules
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1 / 05

Special Edition
Solvias Salt and Polymorphism Programs:
An Integrated Approach to Solid-State Development
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2 / 04

Regulatory Changes in Antibiotic Analytics
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Palladium Catalyzed Carbonylation of Haloaromatics
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UV-Spector - Fiberoptic inline UV-VIS process spectrometer
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Reliable Stability Management in Compliance with ICH Guidelines
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1 / 04

Quality Control of Protein Therapeutics: ICH Guideline Q6B
Solvias, your reliable Partner for the analytics of protein therapeutics
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ARGUS/Dissolution
The cutting edge application software for pharmaceutical dissolution testing
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Second Generation Solvias CN- and CC-Coupling Catalyst
SK-CC02-A
Easy to handle, excellent stability, and improved reactivity
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From Daunorubicin to Doxorubicin: A New Synthesis Process
A cutting edge, robust, economical, and ecological method
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